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Why the elevation of HIF-1α in the intestinal tissues of UC patients did not play a protective role and alleviate colitis, we speculate that the pathologically elevated level of HIF-1α may not be sufficient to play a protective effect by inducing the expression of relevant protective genes, therefore, intervention with PHDs inhibitor (DMOG) in this study resulted in increasingly stable expression levels of HIF-1α in the intestines of colitis mice, contributing to the protection of intestinal barrier function by inducing the expression of protective genes