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Initially, pancreatic β-cells attempt to compensate for decreased sensitivity to insulin action by increasing the rate of insulin synthesis and release through hypertrophic and hyperplastic processes in pancreatic β-islets to improve glucose sensing until the compensatory potential of the pancreas is exhausted (126, 127)

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[DOI] [PubMed] [Google Scholar] 4.Tsoupras A., Lordan R., Zabetakis I

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