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Indeed, we observed that electron-dense particles in Atp7b −/− :Prnp −/− animals accumulated inside endo-lysosomal organelles rather than mitochondria (Supplementary Fig
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These were L-NAME responsive/L-arginine responsive, L-NAME responsive/L-arginine non-responsive, L-NAME non-responsive/L-arginine responsive, opposite or parallel, NO-specific (L-NAME and L-arginine counteract each other’s response), or NO-non-specific (L-NAME and L-arginine do not counteract each other’s response) (Table 3)