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BPC 157 may directly protect endothelium (13), influence NO-system, counteract the effect of both NOS-inhibitor and NO-precursor (14, 15) as well as over expression of endothelin (16)
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Specifically, matrine could serve as an autophagy inhibitor to suppress mitochondrial energy production and thus inhibiting KRAS proto-oncogene, GTPase (KRAS)-driven PCC progression [231]
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