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NOSIP (e NOS - i nteracting p rotein) is another protein residing in caveolae that interacts with eNOS and promotes its translocation from the plasma membrane and inhibit NO production ( tubulin ( Interaction with GPCRs – Evidence from in vitro studies indicates that eNOS can interact with the juxtamembranous regions of AT 1 R, ET A , ET B and bradykinin B 2 receptor (Marrero et al., 1999)