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In the IRI model, elevated expression of the E3 Ub-protein ligase HMG-CoA reductase degradation protein 1 (HRD1) increases ubiquitinated degradation of the β-catenin degradation complex, stabilizes β-catenin proteins, and thereby enhances Wnt / β-catenin signaling[50]

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As such if reversible hydride exchange were occurring the NADPH would become stereospecifically enriched with deuterium at the nicotinamide 4-position