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Newer generations of multi-target CAR and STAb-T immunotherapeutics: NEXT CART Consortium as a cooperative effort to overcome current limitations

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The diminished protein thiol content, susceptibility to perturbations in methionine metabolism, evidence of chronic low-grade hepatic pathology and occasional spontaneous death in mice with TR/GR-null livers suggest that homeostasis in these animals is at the ‘brink of failure’