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Notably, the activities of the 3 key enzymes participating in the leukotriene pathway, namely, 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene A4 hydrolase, were markedly increased in the lesions of patients with active IBD, indicating that an elevated LTB4 release may contribute to neutrophil accumulation during IBD

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The onset of cisplatin-induced neuropathy is variable, with some patients reporting the first appearance of symptoms after the first dose, and others after 12 cycles of therapy (Cersosimo, 1989