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Triparanol, an inhibitor of the conversion of lanosterol to cholesterol, has also been shown to not only induce cataract formation but also increase tissue lanosterol levels 32,33,34

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Since we had observed an up-regulation of genes involved in GSH recycling (Table 2), we also tested the GSH recycling inhibitor 6-aminonicotinamide (6-AN), which blocks the oxidative branch of the pentose phosphate pathway that is necessary for reduction of oxidized GSSG into GSH