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These findings validate the therapeutic targeting of the system Xc− pathway, although challenges related to tumor selectivity and potential systemic toxicity remain
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GSTP1-1 overexpression is an important factor involved in tumor chemoresistance (Díez-Dacal and Pérez-Sala, GSTP1-1 also keeps important direct or indirect interactions with the mechanism of action of drugs such as acetaminophen (McGarry et al., Interaction of GSTP1-1 with inflammatory mediators GSTP1-1 also displays multiple interactions with inflammation: it is induced by proinflammatory stimuli, but this could exert a negative feedback on the inflammatory response
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