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Among lncRNAs, MALAT1, lincRNA-p21, TUG1, and H19 have been identified as key modulators: MALAT1 associates with UVB-induced senescence and photoaging in dermal fibroblasts and may have analogous roles in melanocytes, while lincRNA-p21 mediates p53-dependent apoptosis and cell cycle arrest to prevent malignant transformation 107

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Additionally, compounds can also be evaluated for their impact on cells through in vitro experiments, such as cell culture experiments

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