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[DOI] [PMC free article] [PubMed] [Google Scholar] 121.Barrett C.W., Ning W., Chen X., Smith J.J., Washington M.K., Hill K.E., Coburn L.A., Peek R.M., Chaturvedi R., Wilson K.T., et al

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The morpholine ring is a privileged pharmacophore element in PI3K inhibitors, frequently positioned within the hydrophilic portion of the ATP-binding pocket to enhance hydrogen-bonding, solubility, and pharmacokinetics [89]