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α-KG is considered an important cofactor for enzymes participating in epigenetic modification 26

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Commonly used experimental markers in preclinical studies include lipid peroxidation products (malondialdehyde [MDA], 4-hydroxynonenal [4-HNE]), iron indices (Fe² + /Fe³ + ratio, ferritin), glutathione system parameters (GSH/GSSG ratio, GPX4 activity, SLC7A11 expression), ferroptosis regulatory proteins (GPX4, ACSL4, PTGS2, xCT), genetic markers (SNPs in GPX4/SLC7A11), lipidomics signatures (oxidized phospholipids)