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At this stage, the primary role of the innate immune system is the clearance of necrotic cells and pathogens, but it inevitably causes acute BBB disruption ( Adaptive immune responses, in contrast, gradually dominate during the subacute phase, typically becoming prominent 1–3 days after ischemia and potentially persisting for several weeks (92)

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doi: 10.1111/ctr.13544 342 CornelyOAArikan-AkdagliSDannaouiEGrollAHLagrouKChakrabartiAet al