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Any of the weight loss drugs mentioned will result in abdominal fat reduction, with those in the GLP-1 category having the highest response rates of currently available options

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4.3.3 HMGB1/5HT7R/Nrf2/xCT/GPX4 While HMGB1 functions as a DAMP and promotes inflammation, it has also been reported to promote ferroptosis via promoting hepcidin expression and secretion (which blocks iron efflux and increases intracellular iron level) and by suppressing the Nrf2/HO-1 axis (Davaanyam et al., 2023