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In response to oxidative stress or other exogenous insults, keratinocytes and melanocytes activate the expression of Nrf2 , and then, the cells synthesize detoxification enzymes, such as γ -glutamylcysteine synthetase, heme oxygenase-1, and glutathione S-transferase, to mitigate the oxidative stress [33–35]
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doi: 10.1155/2023/9721375 112 HaslbeckKMNeundörferBSchlötzer-SchrehardttUBierhausASchleicherEPauliEet al
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