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Designed and synthesized matrices have also addressed limitations of traditional SOMs, ,, offering enhanced ionization efficiency, reduced background interference (via higher molecular weight), lower volatility for small molecules, and improved structural analysis capabilities
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Cellular ferroptosis susceptibility has also been demonstrated to be tuned by iron-handling pathways, including transferrin uptake (via TFR1 modulation) [8,9] , iron export (via ferroportin knockout) [10,11] , iron storage in ferritin and ferritin degradation (ferritinophagy) [12,15]
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