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However, the electrons involved in mitochondrial shuttling can be easily transferred to the mitochondrial matrix, resulting in the conversion of O 2 to superoxide (O 2 − ), a critical source of mitochondrial oxidative stress ( 2 − into hydrogen peroxide (H 2 O 2 ), which is then further processed by glutathione peroxidase (GPx) and peroxidase (PRx) to generate water (H 2 O), thereby facilitating the clearance of ROS (Ruszkiewicz and Albrecht, 2015
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