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These approaches provide valuable insights into ceramide-mediated apoptosis mechanisms induced by cannabinoids and flavonoid-mediated oxidative stress modulation, highlighting their impact on cancer cell vulnerability

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We found that in comparison to Ataxia Telangiectasia Mutated-wild type chronic lymphocytic leukemia, pro-oxidant treatment of Ataxia Telangiectasia Mutated-null cells led to reduced binding of NF-E2 p45-related factor-2 to antioxidant response elements and thus decreased expression of target genes