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This is because the structure of FB 1 resembles sphingoid bases which regulate cell growth, differentiation, transformation and apoptosis, and so it is not surprising that FB 1 can alter growth of certain mammalian cells

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Natural killer cell-mediated immune resistance It has been demonstrated that the innate immune system, which includes neutrophils, macrophages, antigen-presenting cells (APCs), and natural killer (NK) cells, has antitumor effects independent of adaptive immunity [215]