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In another study, 30 days of oral administration of 200 and 400 mg/kg of date seed methanolic extract resulted in a significant reversal of LPS-induced memory impairment, elevated the AChE levels, lowered the COX-2, lowered the TNF- α and IL-6, elevated the anti-inflammatory markers such as IL-10 and TGF-β1 in brain tissue of rats

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If it is unclear which is the major cause of pain, inject the most distal joint first to avoid confusion from a local anaesthetic block of the surrounding cutaneous nerves