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MitoQ also provides cardioprotective effects against heart failure, as demonstrated by its ability to rescue cardiac function in a mouse model of pressure overload-induced heart failure [97] and to attenuate cardiac remodeling by regulating the expression of genes associated with remodeling, thereby preventing heart failure in an ex vivo mouse model [93]

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It was obtained as a kind gift from Dr P Boukamp (DKFZ, Heidelberg University, Germany), who also supplied us with the H-ras-transfected variant of HaCaT cells