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Conserved class B GPCR activation by a biased intracellular agonist

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IPR has become a significant tool for generic companies because it offers a faster and cheaper path to patent invalidation than district court litigation: IPR proceedings typically resolve within 12-18 months and cost $300,000-$1 million per petition, compared to district court patent litigation that can cost $5-30 million and take 3-5 years [19]