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PATHOGENESIS OF ALCOHOLIC LIVER DISEASE The pathogenesis of alcoholic liver disease involves multiple factors including hepatocyte damage due to alcohol and its metabolites, cholestasis, recruitment and activation of innate immune cells by gut-derived pro-inflammatory danger signals, Kupffer cells, and recruited macrophages and neutrophils in the liver
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Koenig et al., 2017), and GABA metabolism in astrocytes plays an important role in supporting the synthesis of glutamine (Andersen and Jakobsen, 2020)