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At optimal concentrations, GHK-Cu increases mRNA production for collagen types I and III, elastin, proteoglycans, and glycosaminoglycans, while laboratory studies show that topical application for 12 weeks improves collagen production in 70% of subjects compared to 50% with vitamin C and 40% with retinoic acid

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Per example, in multiple sclerosis patients Acinetobacter calcoaceticus and Akkermansia muciniphila increased production of proinflammatory Th1 phenotype of peripheral mononuclear cells [35]