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In EAhy926 and HBEC-5i cells exposed to a mixture of homocysteine, adenosine, and tumor necrosis factor (TNF) (DL Hcy Ado TNF), GA effectively restored DNMT1 expression, reduced the activity of the chymotrypsin-like proteasome, significantly inhibited caspase-3 expression, and alleviated apoptotic effects and granule formation (Kam et al., 2014)

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We present a comprehensive overview of the mechanisms through which flavonoids exert their beneficial effects