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The apparent discrepancy between the cytotoxic potencies of the thiol compounds and their respective rates of H 2 O 2 formation in the reconstituted reaction mixture (in the presence of catalytically active SOD1) was reconciled when thiol oxidation was performed in the presence of cystine (oxidized cysteine dimer, CS-SC, 200 μM) – a component of the standard DMEM cell growth medium used in our cytotoxicity experiments
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