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Further, increased Nrf2 levels promote the expression of HO-1, superoxide dismutase (SOD), and glutathione (GSH) and decrease that of malonic dialdehyde (MDA) (Chang et al., 2024), simultaneously, Nrf2 negatively regulates the activation of LPS-induced NF-κB signaling, inhibits the activity of the NF-κB pathway, and suppresses NLRP3 inflammatory vesicles (Xie et al., 2023
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NADPH is then consumed as it regenerates the reduced form of CoQ 10
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