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Changes in SCFA metabolism, increased intestinal permeability and LPS activation of TLR and inflammasomes, endogenous ethanol production, decreased choline availability and TMA (trimethylamine) production have all been implicated in this pathological process.[59] Human studies have compared gut microbiota composition between patients with NAFLD, NASH, NAFLD cirrhosis, and healthy liver as controls in order to discover gut microbiota or microbiota-related metabolite signatures.[60] Such signatures could be used as non-invasive diagnostic tools helpful for the management of these patients, instead of the standard liver biopsy that nowadays is imperative to assess disease screening or progression.[61] QUERCETIN, LIVER DISEASE AND NAFLD Several studies have been published highlighting the hepatoprotective role of QE [Table 1]
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