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Compounds within Table 1 have also been assessed as follows: Assessment of HGF mimetic activity: HGF mimetic activity was typically assessed by one or both of two methods: augmentation of HGF-dependent c-Met phosphorylation in HEK293 cells, or 2) augmentation of HGF-dependent cell scattering in MDCK cells

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The most severe malnutrition, which is accompanied by a significant reduction in muscle mass, generally is found in those alcoholics who are hospitalized for medical complications of alcoholism (e.g., alcohol-related liver disease or other organ damage)