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(2) modulation of phosphodiesterase enzyme activity allowing the inhibition of pro-inflammatory mediators such as interleukin-1 (IL-1), IL-6, C-reactive protein (CRP), nuclear factor kappa B (NF-kB), cyclooxygenase 1 (COX-1), and cyclooxygenase 2 (COX-2) [31,32,35]

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