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Additionally, enzymes such as xanthine oxidase and nitric oxide synthase are activated, generating ROS that react with nitric oxide (NO) to form peroxynitrite, further aggravating oxidative stress
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In rats experiencing chronic water avoidance stress (1 h/7 days), experimental studies have shown that the colonic mast cell infiltration and permeability increased, as evidenced by the TEER decrease and HRP (44 kDa) flux increase
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