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Fisetin induced apoptosis through both intrinsic and extrinsic pathways, as evidenced by increased expression of BAX, BAK1, caspase-9, and APAF1, along with decreased BCL-2 in the intrinsic pathway, and upregulation of FAS, FASL, TNF-family ligands, and caspase-8 in the extrinsic pathway [21]
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Who Should Be Especially Cautious Individuals with known copper imbalance Those with complex autoimmune histories People self-experimenting without diagnostic clarity Anyone treating pain without confirming structural drivers Physician oversight does not guarantee outcomes, but it reduces unnecessary variables and improves sequencing logic
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