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Similarly, one general approach, called multisubstrate adduct, can be applied in DNMTi design, in which the two substrates SAM and cytosine analog are combined into one single molecule

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Furthermore, our recent studies demonstrate that IGF-I treatment enhances the ability of osteoblasts and chondrocytes to induce osteoclast formation in the corresponding co-cultures (osteoblasts/osteoclasts or chondrocytes/osteoclasts), and this effect could be blocked by a specific peptide that interferes with the EphB4-ephrinB2 interactions (manuscript in submission)

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