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Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain

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Despite compelling preclinical evidence, clinical translation remains limited: no mitochondrial-targeted therapy has yet achieved FDA approval for TBI, though MitoQ and related compounds are undergoing safety evaluations in other neurodegenerative contexts, providing a translational springboard for future trials (Khalaf et al., 2022)