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Similarly, Janus kinase and STING inhibitors did not rescue the phenotype, indicating that increased type I interferon and STING-signalling are not sufficient to cause increased cell death in isolation
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These hub genes, particularly BCL-2, GSK3B, MAO-B, and MAO-A are critical players in the network as indicated by their topological metrics highlighting their central roles in apoptosis regulation, dopamine metabolism, and neuroprotection, underscoring the molecular mechanisms through which resveratrol might exert its beneficial effects in Parkinson’s disease