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Mitochondrial GSH comprises approximately 10–15% of total cellular GSH, with a similar concentration to cytosolic GSH, primarily maintained by GSH transport [42]
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HIF-1α and BMAL1 co-regulate intracellular oxidative stress levels under hypoxic conditions Hypoxia can diminish the osteogenic effect during bone regeneration and proliferation due to its direct suppression of cell activity, as well as its promotion of pro-inflammatory mediators such as ROS
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