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For metabolite confirmation, an in-house spectral library was used to verify mass detection at MS1 level and matching retention time (67)
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These anti-inflammatory properties of BROM are attributed to various mechanisms, including decreased plasma fibrinogen levels, reduced bradykinin activity, increased serum fibrinolytic activity, decreased levels of prostaglandin E2 (PGE2) and thromboxane A2 (TXA2), and the modulation of adhesion molecules, such as intercellular adhesion molecule -1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-, P- and L-selectin (endothelial-, platelet- and leukocyte-selectin), CD44, and integrins (α4β1 and αLβ2) on immune cell surfaces involved in the pathogenesis of RA [172,173,174,175,176]