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In summary, a large amount of clinical evidence shows that iron storage indicators, oxidative stress-related indicators, and ferroptosis-related genes are related to the occurrence of DM and can be used as targets for diagnosis and treatment

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Although earlier studies did not show the interaction between S100A2 and RAGE, recent studies showed a micromolar affinity and strict calcium-dependent interaction between S100A2 and RAGE via the V-domain of RAGE (64) ( Figure 3 )